Best bets for Thursday Night Football NFL Week 10

Thursday Night Football in NFL Week 10 features an NFC East showdown between the Washington Commanders and New York Giants, with both teams looking to grab an important divisional win. There are several intriguing player prop opportunities heading into the matchup, including a quarterback who can make plays with his arm and legs, a running back with a manageable rushing total, and two tight ends with favorable receiving lines. Here are four of the best bets to consider for NFL Week 10.MORE:Top 10 NFL teams: Rankings updated after trade deadlineJayden Daniels OVER 199.5 passing + rushing yardsOct 19, 2026; Santa Clara, California, USA; Washington Commanders quarterback Jayden Daniels (5) throws a pass during the first quarter against the San Francisco 49ers at Levi’s Stadium. Mandatory Credit: Cary Edmondson-Imagn ImagesDaniels has averaged approximately 250 combined passing and rushing yards per game this season, giving him a substantial cushion above the 199.5-yard line. He has exceeded this number in four of his six appearances, including three consecutive games with at least 240 total yards.His previous meeting with the Giants is particularly encouraging. Daniels finished that game with 199 passing yards and 103 rushing yards for 302 total yards. New York has also allowed the seventh-most rushing yards to opposing quarterbacks, giving Daniels another avenue to reach this number. The combination of his passing production and rushing ability makes this an appealing over.Cam Skattebo OVER 44.5 rushing yardsOct 4, 2026; East Rutherford, New Jersey, USA; New York Giants running back Cam Skattebo (44) warms up before the game at MetLife Stadium. Mandatory Credit: Vincent Carchietta-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)Skattebo is averaging 59.7 rushing yards per game this season, comfortably above the 44.5-yard threshold. He has surpassed this number in five of his seven appearances, including a 124-yard performance against Houston.He also has a positive recent matchup against Washington. Skattebo rushed for 59 yards on 13 carries in the first meeting between these teams, averaging 4.5 yards per attempt. He doesn’t need a massive workload to cash this prop, and his season-long production suggests 45 rushing yards is a realistic target.MORE:Bold predictions for Week 10 of 2026 NFL seasonChig Okonkwo OVER 24.5 receiving yardsNov 8, 2026; Landover, Maryland, USA; Washington Commanders tight end Chig Okonkwo (85) runs with the ball past Los Angeles Rams defensive back Cam Lampkin (21) during the fourth quarter at Northwest Stadium. Mandatory Credit: Amber Searls-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)Okonkwo has averaged 39.8 receiving yards per game this season, well above the 24.5-yard line. He has also recorded at least 32 receiving yards in four of his last five games, including 57 yards against the Rams in Week 9.The tight end has already had success against the Giants, recording 60 receiving yards in their first meeting. That performance gives this matchup an encouraging recent reference point. While New York has been relatively strong against opposing tight ends this season, Okonkwo’s low yardage requirement and recent production make the over worth considering.MORE:3 NFL trade deadline deals that would have changed everything in 2026Isaiah Likely OVER 3.5 receptionsNew York Giants tight end Isaiah Likely (9) throws the football in the air after scoring a touchdown during a week one opening game between the New York Giants and Dallas Cowboys at Metlife Stadium on Sunday, Sept. 13, 2026, in East Rutherford, NJ. Credit: USA TODAY Network via Reuters Connect (Reuters)Likely has been a consistent target in the Giants’ passing game, averaging 5.8 receptions per game through eight appearances. He has caught at least four passes in six of those eight games, making the over 3.5 receptions a reasonable target.His previous performance against Washington makes this pick even more appealing. Likely caught 11 passes on 13 targets for 94 yards and two touchdowns in that Week 5 matchup. He has also recorded at least five receptions in four of his last five games. With a requirement of just four catches, Likely has a strong statistical case to clear this number.****Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.****— Enjoy free coverage of the top news & trending stories with The Big Lead Newsletter —